Lomitapide mesylate

Key Product Details

Product Description

Lomitapide mesylate is a potent inhibitor of microsomal triglyceride transfer protein (IC₅₀ = 8 nM). Lomitapide inhibits or normalizes lipoprotein production in rodents and in a rabbit model of hypercholesterolemia. Lomitapide is antimalarial; it inhibits hemozoin formation and growth of CQ-sensitive (PfNF54) and multidrug-resistant (PfK1) strains of P. falciparum (IC₅₀ values are 0.56 µM and 0.69 µM respectively). Orally bioavailable.

Product Specifications for Lomitapide mesylate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Lomitapide mesylate

The following data is based on the product molecular weight 789.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.33 mL	31.65 mL	63.30 mL
1 mM	1.27 mL	6.33 mL	12.66 mL
2 mM	0.63 mL	3.17 mL	6.33 mL
10 mM	0.13 mL	0.63 mL	1.27 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Robl A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors. J.Med.Chem. 2001 PMID: 11300866
• Sousa Lapatinib, Nilotinib and Lomitapide inhibit haemozoin formation in malaria parasites. Molecules 2020 PMID: 32235391
• Wetterau An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 1998 PMID: 9784135

Product Documents for Lomitapide mesylate