Lonafarnib

Catalog # Availability Size / Price Qty
6265/10
6265/50

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Lonafarnib | CAS No. 193275-84-2 | Protein Prenyltransferase Inhibitors
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Description: Potent farnesyltransferase inhibitor

Chemical Name: 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Lonafarnib is a potent farnesyl transferase inhibitor (IC50 = 1.9 nM). Inhibits farnesylation of RAS. Also inhibits Pgp transport (IC50 < 3 μM) and increases potency and anticancer activity when used in conjunction with cytotoxic Pgp substrates. Inhibits neovascularization by affecting cell motility. Orally bioavailable.

Technical Data

M.Wt:
638.82
Formula:
C27H31Br2ClN4O2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
193275-84-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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