Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Biological ActivityLosartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.
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Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
Wong et al.
Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent.
Wong et al.
DuP 753 is a specific antagonist for the angiotensin receptor.
Rhaleb et al.
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Kuba et al.
Citations for Losartan potassium
The citations listed below are publications that use Tocris products. Selected citations for Losartan potassium include:
9 Citations: Showing 1 - 9
Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
Authors: Moreno-Santos Et al.
Behav.Brain Res. 2020;
Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
Authors: Lee Et al.
Sci Rep 2019;9:12149
Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer.
Authors: Dominska Et al.
Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor.
Authors: Thieme and Oliveira-Souza
PLoS One 2015;10:e0122265
Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.
Authors: Santhekadur Et al.
FEBS Open Bio 2014;4:353
PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle.
Authors: Bhattachariya Et al.
Physiol Rep 2014;2
Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice.
Authors: Fang Et al.
Am J Physiol Heart Circ Physiol 2013;304:H816
Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
Authors: Tsai Et al.
EMBO Mol Med 2012;7:e33527
Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
Authors: Leite-Moreira Et al.
Br J Pharmacol 2006;147:690
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We used Losartan as type 1 angiotensin II receptor antagonist in piglet study to prove that hUII-induced MAP elevation and hemodynamic changeswere inhibited by urantide, a UTR antagonist, but not with losartan.