Losartan potassium

Catalog # Availability Size / Price Qty
Losartan potassium | CAS No. 124750-99-8 | Angiotensin AT1 Receptor Antagonists
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Description: Selective, non-peptide AT1 antagonist
Alternative Names: DuP-753

Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt

Purity: ≥99%

Product Details
Citations (15)
Supplemental Products

Biological Activity

Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Losartan potassium

The citations listed below are publications that use Tocris products. Selected citations for Losartan potassium include:

15 Citations: Showing 1 - 10

  1. Angiotensin II increases respiratory rhythmic activity in the preBötzinger complex without inducing astroglial calcium signaling.
    Authors: Swen Et al.
    Front Cell Neurosci  2023;17:1111263
  2. Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids.
    Authors: Justin Et al.
    iScience  2022;25:103818
  3. Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
    Authors: Moreno-Santos Et al.
    Behav.Brain Res.  2021;397
  4. Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts.
    Authors: Ariel Et al.
    Cells  2021;10
  5. The Impact of Ang-(1-9) and Ang-(3-7) on the Biological Properties of Prostate Cancer Cells by Modulation of Inflammatory and Steroidogenesis Pathway Genes.
    Authors: Tomasz Et al.
    Int J Mol Sci  2020;21
  6. The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
    Authors: Diego Et al.
    Sci Signal  2020;13
  7. Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
    Authors: Lee Et al.
    Sci Rep  2019;9:12149
  8. Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer.
    Authors: Dominska Et al.
    Sci.Rep.  2018;8:15772
  9. Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN.
    Authors: Eero Et al.
    Neuropharmacology  2018;135:163-171
  10. Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor.
    Authors: Thieme and Oliveira-Souza
    PLoS One  2015;10:e0122265


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