Losartan potassium
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Purity: ≥99%
Biological Activity
Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
Wong et al.
J.Pharmacol.Exp.Ther., 1990;255:584 -
Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent.
Wong et al.
J.Pharmacol.Exp.Ther., 1990;252:719 -
DuP 753 is a specific antagonist for the angiotensin receptor.
Rhaleb et al.
Hypertension, 1991;17:480 -
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Kuba et al.
Nat.Med., 2005;11:875
Product Datasheets
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Citations for Losartan potassium
The citations listed below are publications that use Tocris products. Selected citations for Losartan potassium include:
9 Citations: Showing 1 - 9
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Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
Authors: Moreno-Santos Et al.
Behav.Brain Res. 2021;397
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Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
Authors: Lee Et al.
Sci Rep 2019;9:12149
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Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer.
Authors: Dominska Et al.
Sci.Rep. 2018;8:15772
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Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor.
Authors: Thieme and Oliveira-Souza
PLoS One 2015;10:e0122265
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Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.
Authors: Santhekadur Et al.
FEBS Open Bio 2014;4:353
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PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle.
Authors: Bhattachariya Et al.
Physiol Rep 2014;2
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Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice.
Authors: Fang Et al.
Am J Physiol Heart Circ Physiol 2013;304:H816
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Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
Authors: Tsai Et al.
EMBO Mol Med 2012;7:e33527
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Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
Authors: Leite-Moreira Et al.
Br J Pharmacol 2006;147:690
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