Losartan potassium

Tocris Bioscience | Catalog # 3798

Selective, non-peptide AT1 antagonist
Tocris Bioscience

Key Product Details

Description

Selective, non-peptide AT1 antagonist

Alternative Names

DuP-753
View all Angiotensin AT1 Receptor Antagonists »

Product Description

Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Product Specifications for Losartan potassium

Molecular Weight

461.00

Formula

C22H22ClKN6O

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt

CAS Number

124750-99-8

PubChem ID

11476710

InChI Key

OXCMYAYHXIHQOA-UHFFFAOYSA-N

SMILES

CCCCC1=NC(Cl)=C(CO)N1CC2=CC=C(C3=CC=CC=C3C(N=N4)=NN4[K])C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.1 100
DMSO 46.1 100

Preparing Stock Solutions for Losartan potassium

The following data is based on the product molecular weight 461.00.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.85 mL 21.69 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 32 publications citing the usage of this product.

Product Documents for Losartan potassium

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Losartan potassium

For research use only

Citations for Losartan potassium

Customer Reviews for Losartan potassium (1)

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  • Losartan as type 1 angiotensin II receptor antagonist in piglet study
    Name: Hiteshkumar Soni
    Species: Piglet
    Assay Type: In Vivo
    Verified Customer | Posted 01/10/2018
    We used Losartan as type 1 angiotensin II receptor antagonist in piglet study to prove that hUII-induced MAP elevation and hemodynamic changes were inhibited by urantide, a UTR antagonist, but not with losartan.
    Losartan potassium 3798

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