Losartan potassium

Catalog # Availability Size / Price Qty
Losartan potassium | CAS No. 124750-99-8 | Angiotensin AT1 Receptor Antagonists
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Description: Selective, non-peptide AT1 antagonist
Alternative Names: DuP-753

Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt

Purity: ≥99%

Product Details
Citations (9)
Supplemental Products

Biological Activity

Losartan potassium is a selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent. Attenuates lung damage in a mouse model of SARS-CoV infection.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Losartan potassium

The citations listed below are publications that use Tocris products. Selected citations for Losartan potassium include:

9 Citations: Showing 1 - 9

  1. Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats.
    Authors: Moreno-Santos Et al.
    Behav.Brain Res.  2021;397
  2. Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
    Authors: Lee Et al.
    Sci Rep  2019;9:12149
  3. Angiotensin 1-7 modulates molecular and cellular processes central to the pathogenesis of prostate cancer.
    Authors: Dominska Et al.
    Sci.Rep.  2018;8:15772
  4. Renal hemodynamic and morphological changes after 7 and 28 days of leptin treatment: the participation of angiotensin II via the AT1 receptor.
    Authors: Thieme and Oliveira-Souza
    PLoS One  2015;10:e0122265
  5. Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.
    Authors: Santhekadur Et al.
    FEBS Open Bio  2014;4:353
  6. PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle.
    Authors: Bhattachariya Et al.
    Physiol Rep  2014;2
  7. Compromised regulation of tissue perfusion and arteriogenesis limit, in an AT1R-independent fashion, recovery of ischemic tissue in Cx40(-/-) mice.
    Authors: Fang Et al.
    Am J Physiol Heart Circ Physiol  2013;304:H816
  8. Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
    Authors: Tsai Et al.
    EMBO Mol Med  2012;7:e33527
  9. Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.
    Authors: Leite-Moreira Et al.
    Br J Pharmacol  2006;147:690


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