Catalog Number: 3798
Alternate Names: DuP-753
Chemical Name: 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt
Biological Activity
Selective non-peptide angiotensin AT1 receptor antagonist. Inhibits the contractile effects of angiotensin II on rabbit aorta and jugular vein (pA2 = 8.27). Orally active antihypertensive agent.
Technical Data
  • M.Wt:
    461
  • Formula:
    C22H22ClKN6O
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    124750-99-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).
    Wong et al.
    J.Pharmacol.Exp.Ther., 1990;255:584
  2. Nonpeptide angiotensin II receptor antagonists. VIII. Characterization of functional antagonism displayed by DuP an orally active antihypertensive agent.
    Wong et al.
    J.Pharmacol.Exp.Ther., 1990;252:719
  3. DuP 753 is a specific antagonist for the angiotensin receptor.
    Rhaleb et al.
    Hypertension, 1991;17:480
Citations:

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