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LP 922761

6229 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6229/10
6229/50
Other Kinase Inhibitors Small Molecule
1 Image
Description: Potent AAK1 inhibitor; peripherally restricted

Chemical Name: tert-Butyl (2-((3-(4-carbamoylphenyl)imidazo[1,2-b]pyridazin-6-yl)amino)ethyl)(methyl)carbamate

Purity: ≥98%

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Biological Activity

Potent AAK1 inhibitor (IC50 values are 4.8 and 7.6 nM in enzyme and cell assays, respectively). Exhibits some selectivity for AAK1 over BIKE, and exhibits no significant activity at opioid, adrenergic α2 or GABAA receptors. Orally bioavailable. Peripherally restricted.

Technical Data

M.Wt:
410.47
Formula:
C21H26N6O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1454808-95-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibition of AAK1 kinase as a novel therapeutic approach to treat neuropathic pain.
    Kostich et al.
    J.Pharmacol.Exp.Ther., 2016;358:371

Product Datasheets

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