LP 99

Key Product Details

Product Description

LP 99 is a selective BRD7 and BRD9 inhibitor (K_d values are 99 and 909 nM, respectively) that exhibits selectivity for BRD7/9 over a panel of 48 bromodomains (at 10 μM). LP 99 inhibits interactions with histones H3.3 and H4 at low micromolar concentrations, and decreases the level of IL-6 secreted from LPS-stimulated THP-1 cells, in vitro. A negative control for LP 99, ent-LP 99 (Cat.No. 5497), is also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LP 99 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LP 99 is reviewed on the chemical probes website.

Product Specifications for LP 99

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LP 99

The following data is based on the product molecular weight 516.05.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.94 mL	9.69 mL	19.38 mL
5 mM	0.39 mL	1.94 mL	3.88 mL
10 mM	0.19 mL	0.97 mL	1.94 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Clark LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor. Angew.Chem.Int.Ed.Engl. 2015 PMID: 25864491

Product Documents for LP 99