LP 99

Catalog # Availability Size / Price Qty
5496/5
5496/25
Cat.No. 5496 - LP 99 | C26H30ClN3O4S | CAS No. 1808951-93-0
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Description: Selective BRD7 and BRD9 inhibitor

Chemical Name: N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

Selective BRD7 and BRD9 inhibitor (Kd values are 99 and 909 nM, respectively). Exhibits selectivity for BRD7/9 over a panel of 48 bromodomains (at 10 μM). Inhibits interactions with histones H3.3 and H4 at low micromolar concentrations. Decreases the level of IL-6 secreted from LPS-stimulated THP-1 cells. Negative control ent-LP 99 (Cat.No. 5497) also available.

Technical Data

M.Wt:
516.05
Formula:
C26H30ClN3O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1808951-93-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LP 99 probe summary on the SGC website.

Background References

  1. LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor.
    Clark et al.
    Angew.Chem.Int.Ed.Engl., 2015;54:6217

Product Datasheets

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