Chemical Name: N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Biological ActivitySelective BRD7 and BRD9 inhibitor (Kd values are 99 and 909 nM, respectively). Exhibits selectivity for BRD7/9 over a panel of 48 bromodomains (at 10 μM). Inhibits interactions with histones H3.3 and H4 at low micromolar concentrations. Decreases the level of IL-6 secreted from LPS-stimulated THP-1 cells. Negative control ent-LP 99 (Cat.No. 5497) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
LP99: discovery and synthesis of the first selective BRD7/9 bromodomain inhibitor.
Clark et al.
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