LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) is a 145 kDa type I transmembrane glycoprotein that shares 45 - 50% amino acid (aa) identity with two other mammalian LRIG proteins. LRIG1 shows highest expression in subsets of glial cells in brain, and certain epithelia in liver, stomach, small intestine and skeletal muscle. Within the cell, LRIG1 is expressed in the perinuclear region as well as on the surface. LRIG1 binds ErbB receptors and promotes their ubiquitination, internalization and destruction.
LRIG1 Antibody (440710) [Janelia Fluor® 646]
Novus Biologicals | Catalog # FAB3688J
Key Product Details
Species Reactivity
Mouse
Applications
Blockade of Receptor-ligand Interaction
Label
Janelia Fluor 646
Antibody Source
Monoclonal Rat IgG2A Clone # 440710
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Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse LRIG1
Ala37-Thr794
Accession # P70193
Ala37-Thr794
Accession # P70193
Specificity
Detects mouse LRIG1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human LRIG3 is observed.
Clonality
Monoclonal
Host
Rat
Isotype
IgG2A
Applications for LRIG1 Antibody (440710) [Janelia Fluor® 646]
Application
Recommended Usage
Blockade of Receptor-ligand Interaction
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: LRIG1
Long Name
Leucine-rich Repeats and Immunoglobulin-like Domains 1
Alternate Names
Img, LIG1
Gene Symbol
LRIG1
Additional LRIG1 Products
Product Documents for LRIG1 Antibody (440710) [Janelia Fluor® 646]
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for LRIG1 Antibody (440710) [Janelia Fluor® 646]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Related Research Areas
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Associated Pathways
