LRRK2-IN-1

Tocris Bioscience | Catalog # 4273

Potent and selective LRRK2 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective LRRK2 inhibitor
View all LRRK2 Inhibitors »

Product Description

LRRK2-IN-1 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2). Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC50 values are 6 and 13 nM respectively). Causes dephosphorylation, ubiquitination and degradation of LRRK2. Inhibits IFN-γ-induced monocyte maturation in vitro.

Licensing Information

Sold under license from the Dana-Farber Cancer Institute.

Product Specifications for LRRK2-IN-1

Molecular Weight

570.69

Formula

C31H38N8O3

Storage

Store at -20°C

Purity

≥98%

Chemical Name

5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

CAS Number

1234480-84-2

PubChem ID

46843906

InChI Key

IWMCPJZTADUIFX-UHFFFAOYSA-N

SMILES

O=C2C3=C(C=CC=C3)N(C)C1=NC(NC4=C(OC)C=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4)=NC=C1N2C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 57.01 100

Preparing Stock Solutions for LRRK2-IN-1

The following data is based on the product molecular weight 570.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.75 mL 8.76 mL 17.52 mL
5 mM 0.35 mL 1.75 mL 3.50 mL
10 mM 0.18 mL 0.88 mL 1.75 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.

Product Documents for LRRK2-IN-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LRRK2-IN-1

For research use only

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