Chemical Name: Methyl 4-hydroxy-3-[[2-(4-tricyclo[22.214.171.124,7]dec-1-ylphenoxy)acetyl]amino]benzoate
Biological ActivityLW 6 is a malate dehydrogenase-2 (MDH2) inhibitor (IC50 = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC50 = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.
Eleftheriadis et al.
(Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors.
Lee et al.
A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration.
Ban et al.
PLoS One, 2016;9:e0162568
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for LW 6
There are currently no reviews for this product. Be the first to review LW 6 and earn rewards!
Have you used LW 6?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image