Catalog Number: 2452
Chemical Name: 5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide
Biological Activity
Novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.
Technical Data
  • M.Wt:
    307.35
  • Formula:
    C17H17N5O
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    874902-19-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Eli Lilly and Company
Background References
  1. Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors.
    Dickason-Chesterfield et al.
    Cell Mol.Neurobiol., 2006;26:407
  2. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.
    Alexander and Cravat
    J.Am.Chem.Soc., 2006;128:9699
  3. Identification of a high-affinity binding site involved in the transport of endocannabinoids.
    Moore et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:17852
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 2183240 include:

1 Citations: Showing 1 - 1

  1. Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
    Authors: Gonzalez-Islas Et al.
    PLoS One 2012;32:13597

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