Chemical Name: 5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N-dimethyl-1H-tetrazole-1-carboxamide
Biological ActivityLY 2183240 is a novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors.
Dickason-Chesterfield et al.
Cell Mol.Neurobiol., 2006;26:407
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.
Alexander and Cravat
Identification of a high-affinity binding site involved in the transport of endocannabinoids.
Moore et al.
Citation for LY 2183240
The citations listed below are publications that use Tocris products. Selected citations for LY 2183240 include:
1 Citation: Showing 1 - 1
Tonic and transient endocannabinoid regulation of AMPAergic miniature postsynaptic currents and homeostatic plasticity in embryonic motor networks.
Authors: Gonzalez-Islas Et al.
PLoS One 2012;32:13597
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