Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Biological ActivitySelective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration..
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.
Herron et al.
Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.
Silbaugh et al.
Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
Yokomizo et al.
Citation for LY 255283
The citations listed below are publications that use Tocris products. Selected citations for LY 255283 include:
1 Citation: Showing 1 - 1
Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis.
Authors: Cabral Et al.
PLoS One 2015;3
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for LY 255283
There are currently no reviews for this product. Be the first to review LY 255283 and earn rewards!
Have you used LY 255283?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image