Catalog Number: 2208
Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone
Biological Activity
Selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration.�.
Technical Data
  • M.Wt:
    360.46
  • Formula:
    C19H28N4O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    117690-79-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.
    Silbaugh et al.
    Eur.J.Pharmacol., 1992;223:57
  2. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2.
    Yokomizo et al.
    J.Biol.Chem., 2001;276:12454
  3. Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.
    Herron et al.
    J.Med.Chem., 1992;35:1818
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 255283 include:

1 Citations: Showing 1 - 1

  1. Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis.
    Authors: Cabral Et al.
    PLoS One 2015;3

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