LY 2603618

Catalog # Availability Size / Price Qty
6454/10
6454/50
Cat.No. 6454 - LY 2603618 | C18H22BrN5O3 | CAS No. 911222-45-2
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Description: Potent and selective Chk1 inhibitor

Chemical Name: N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).

Technical Data

M.Wt:
436.3
Formula:
C18H22BrN5O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
911222-45-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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