Chemical Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
Biological ActivityPemetrexed is a high affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
Shih et al.
Cancer Res., 1997;57:1116
Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas.
Rothbart et al.
Cancer Res., 2010;70:10299
Citations for Pemetrexed
The citations listed below are publications that use Tocris products. Selected citations for Pemetrexed include:
2 Citations: Showing 1 - 2
Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs.
Authors: Michael G Et al.
Cancer Res 2021;81:400-413
Simultaneous Control of Endogenous and User-Defined Genetic Pathways Using Unique ecDHFR Pharmacological Chaperones.
Authors: Hui Et al.
Cell Chem Biol 2020;27:622-634.e6
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