High affinity dihydrofolate reductase inhibitor (Ki
= 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki
values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro
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All Tocris products are intended for laboratory research use only.
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
Shih et al.
Cancer Res., 1997;57:1116
Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas.
Rothbart et al.
Cancer Res., 2010;70:10299