LY 266097 hydrochloride
Chemical Name: 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Biological ActivitySelective 5-HT2B receptor antagonist (pKi = 9.3). More than 100-fold selective over 5-HT2A and 5-HT2C. Attenuates amphetamine-induced locomotion in the rat.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT2B) contractile receptor in the rat stomach fundus.
Audia et al.
The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens DArgic pathway activity.
Auclair et al.
Citation for LY 266097 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for LY 266097 hydrochloride include:
1 Citation: Showing 1 - 1
Structural determinants of 5-HT2B receptor activation and biased agonism.
Authors: McCorvy Et al.
Nat Struct Mol Biol 2018;25:787
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