LY 266097 hydrochloride
Chemical Name: 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Biological ActivitySelective 5-HT2B receptor antagonist (pKi = 9.3). More than 100-fold selective over 5-HT2A and 5-HT2C. Attenuates amphetamine-induced locomotion in the rat.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT2B) contractile receptor in the rat stomach fundus.
Audia et al.
The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity.
Auclair et al.
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