Catalog Number: 2451
Chemical Name: N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride
Biological Activity
Potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
Technical Data
  • M.Wt:
    387.88
  • Formula:
    C21H22N3OF.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1217756-94-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from Eli Lilly and Company
Background References
  1. Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input.
    Goadsby and Classey
    Neuroscience, 2003;122:491
  2. 5-HT1F receptor agonists in acute migraine treatment: a hypothesis.
    Ramadan et al.
    Cephalalgia, 2003;23:776
  3. Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
    Lee et al.
    Life Science, 1997;61:2117
Citations:

The citations listed below are publications that use Tocris products. Selected citations for LY 344864 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury.
    Authors: Garrett Et al.
    J Pharmacol Exp Ther 2014;350:257

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