Potent, selective 5-HT1F
receptor agonist (EC50
= 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki
values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ
M for 5-HT1F
receptors respectively). Inhibits neurogenic dural inflammation in vivo
following i.v. and oral administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold under license from Eli Lilly and Company
Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input.
Goadsby and Classey
5-HT1F receptor agonists in acute migraine treatment: a hypothesis.
Ramadan et al.
Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
Lee et al.
Life Science, 1997;61:2117
The citations listed below are publications that use Tocris products. Selected citations for LY 344864 hydrochloride include:
Showing Results 1 - 1 of 1