LY 344864 hydrochloride

Key Product Details

Product Description

LY 344864 hydrochloride is a potent, selective 5-HT_1F receptor agonist (EC₅₀ = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K_i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT_1F, 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_1E, 5-HT_2B, 5-HT_2C, 5-HT_2A and 5-HT₇ receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

Licensing Information

Sold under license from Eli Lilly and Company

Product Specifications for LY 344864 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for LY 344864 hydrochloride

The following data is based on the product molecular weight 387.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.89 mL	25.78 mL
5 mM	0.52 mL	2.58 mL	5.16 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Goadsby and Classey Evidence for serotonin (5-HT)_1B, 5-HT_1D and 5-HT_1F receptor inhibitory effects on trigeminal neurons with craniovascular input. Neuroscience 2003 PMID: 14614913
• Lee Characterization of LY344864 as a pharmacological tool to study 5-HT_1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Science
• Ramadan 5-HT_1F receptor agonists in acute migraine treatment: a hypothesis. Cephalalgia 2003 PMID: 14510923

Product Documents for LY 344864 hydrochloride