LY 344864 hydrochloride
Chemical Name: N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide hydrochloride
Biological ActivityLY 344864 hydrochloride is a potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
5-HT1F receptor agonists in acute migraine treatment: a hypothesis.
Ramadan et al.
Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input.
Goadsby and Classey
Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.
Lee et al.
Life Science, 1997;61:2117
Citations for LY 344864 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for LY 344864 hydrochloride include:
3 Citations: Showing 1 - 3
5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease.
Authors: Scholpa Et al.
Br J Pharmacol 2018;175:348
Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury.
Authors: Garrett Et al.
J Pharmacol Exp Ther 2014;350:257
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for LY 344864 hydrochloride
There are currently no reviews for this product. Be the first to review LY 344864 hydrochloride and earn rewards!
Have you used LY 344864 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image