Catalog Number: 3425
Alternate Names: Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide
Biological Activity
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
Technical Data
  • M.Wt:
    1981.33
  • Formula:
    C94H145N23O24
  • Sequence:
    GWTLNSAGYLLGPPPALALA

    (Modifications: Ala-20 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    143896-17-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes.
    Bartfai et al.
    Proc.Natl.Acad.Sci.USA, 1993;90:11287

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