M40

Catalog # Availability Size / Price Qty
3425/1
M40
1 Image
Description: Potent, non-selective galanin receptor antagonist
Alternative Names: Galanin (1-13)-Pro-Pro-(Ala-Leu-)2Ala amide
Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.

Technical Data

M.Wt:
1981.33
Formula:
C94H145N23O24
Sequence:
GWTLNSAGYLLGPPPALALA

(Modifications: Ala-20 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
143896-17-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes.
    Bartfai et al.
    Proc.Natl.Acad.Sci.USA, 1993;90:11287
  2. Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity.
    Yuan et al.
    J.Pharm.Exp.Ther., 2002;301:488
  3. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
    Lu et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:874

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for M40

The citations listed below are publications that use Tocris products. Selected citations for M40 include:

2 Citations: Showing 1 - 2

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for M40

There are currently no reviews for this product. Be the first to review M40 and earn rewards!

Have you used M40?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.