Biological ActivityM40 is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) (Cat. No. 2696) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine (Cat. No. 0927) and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
(Modifications: Ala-20 = C-terminal amide)
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes.
Bartfai et al.
Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity.
Yuan et al.
A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus.
Lu et al.
Citations for M40
The citations listed below are publications that use Tocris products. Selected citations for M40 include:
2 Citations: Showing 1 - 2
Involvement of galanin and galanin receptor 1 in nociceptive modulation in the central nucleus of amygdala in normal and neuropathic rats.
Sci Rep 2017;7(1):15317
The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability.
Authors: Herring Et al.
J Mol Cell Cardiol 2012;52:667
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