Potent, non-selective galanin receptor antagonist (Ki
values are 1.82 and 5.1 nM at GAL1
respectively) that inhibits galanin (1-29)
(Cat. No. 2696) binding in rat brain in vitro
= 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine
(Cat. No. 0927) and blocks galanin-induced food intake in vivo
. Also exhibits weak partial agonist activity at peripheral GAL2
receptors at doses > 100 nM.
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All Tocris products are intended for laboratory research use only.
Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes.
Bartfai et al.