Macbecin I

Catalog # Availability Size / Price Qty
3061/1
Macbecin I | CAS No. 73341-72-7 | HSP90 Inhibitors
1 Image
Description: Hsp90 inhibitor

Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

Product Details
Citations (1)
Reviews

Biological Activity

Ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).

Technical Data

M.Wt:
558.67
Formula:
C30H42N2O8
Solubility:
Soluble in DMSO
Storage:
Desiccate at -20°C
CAS No:
73341-72-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I.
    Ono et al.
    Gann., 1982;73:938
  2. Natural product origins of Hsp90 inhibitors.
    Uehara et al.
    Curr.Cancer Drug Targets, 2003;3:325
  3. Molecular characterization of macbecin as an Hsp90 inhibitor.
    Martin et al.
    J.Med.Chem., 2008;51:2853

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for Macbecin I

The citations listed below are publications that use Tocris products. Selected citations for Macbecin I include:

1 Citation: Showing 1 - 1

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Macbecin I

There are currently no reviews for this product. Be the first to review Macbecin I and earn rewards!

Have you used Macbecin I?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.