Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
Biological ActivityMacbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I.
Ono et al.
Natural product origins of Hsp90 inhibitors.
Uehara et al.
Curr.Cancer Drug Targets, 2003;3:325
Molecular characterization of macbecin as an Hsp90 inhibitor.
Martin et al.
Citation for Macbecin I
The citations listed below are publications that use Tocris products. Selected citations for Macbecin I include:
1 Citation: Showing 1 - 1
Quantification of Hsp90 availability reveals differential coupling to the heat shock response.
Authors: Alford and Brandman
J Cell Biol 2018;217:3809
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