Macbecin I

Discontinued Product

3061 has been discontinued.
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Macbecin I | CAS No. 73341-72-7 | HSP90 Inhibitors
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Description: Hsp90 inhibitor

Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin

Product Details
Citations (1)

Biological Activity

Macbecin I is an ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368).

Technical Data

Soluble in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I.
    Ono et al.
    Gann., 1982;73:938
  2. Natural product origins of Hsp90 inhibitors.
    Uehara et al.
    Curr.Cancer Drug Targets, 2003;3:325
  3. Molecular characterization of macbecin as an Hsp90 inhibitor.
    Martin et al.
    J.Med.Chem., 2008;51:2853

Product Datasheets

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Citation for Macbecin I

The citations listed below are publications that use Tocris products. Selected citations for Macbecin I include:

1 Citation: Showing 1 - 1


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