MAG/Siglec-4a Antibody (SR1017) - BSA Free

Novus Biologicals | Catalog # NBP3-22143

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Flow Cytometry, Immunoprecipitation

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1017 expressed in HEK293

Format

BSA Free
View all MAG/Siglec-4a Primary Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human MAG/Siglec-4a (Uniprot #: P20916)

Specificity

Detects endogenous levels of total MAG/Siglec-4a

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for MAG/Siglec-4a Antibody (SR1017) - BSA Free

Western Blot: MAG/Siglec-4a Antibody (SR1017) [NBP3-22143] -

Western Blot: MAG/Siglec-4a Antibody (SR1017) [NBP3-22143] - Western blot analysis using NBP3-22143 in Rat brain lysate.

Applications for MAG/Siglec-4a Antibody (SR1017) - BSA Free

Application
Recommended Usage

Flow Cytometry

1:20

Immunoprecipitation

1:50

Western Blot

1:500-1:2000

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAG/Siglec-4a

Myelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination (1). Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG (2). MAG has been implicated in inhibition of nerve regeneration in the CNS. This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron (3). Results also suggest that MAG binds to a specific receptor and initiates a signal transduction cascade to effect inhibition. These results indicate that soluble dMAG detected in vivo could contribute to the lack of regeneration in the mammalian CNS after injury (4).

Long Name

Myelin-associated Glycoprotein

Alternate Names

Siglec-4a, Siglec4a

Gene Symbol

MAG

Additional MAG/Siglec-4a Products

Product Documents for MAG/Siglec-4a Antibody (SR1017) - BSA Free

Certificate of Analysis

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Product Specific Notices for MAG/Siglec-4a Antibody (SR1017) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Glial Lineage Markers

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Protocols

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FAQs

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