MCAM/CD146 Antibody (c264) [FITC]

Novus Biologicals | Catalog # NBP1-28332

Novus Biologicals

Key Product Details

Species Reactivity

Chicken, Turkey

Applications

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # c264
View all MCAM/CD146 Primary Antibodies »

Product Specifications

Immunogen

Mixture of E15 and E16 thymocytes from H.B15, H.B19, and H.B21 chicken embryos

Reactivity Notes

Chicken

Specificity

Chicken MCAM, Mr 98 kDa (protein core approx. 84 kDa)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Scientific Data Images for MCAM/CD146 Antibody (c264) [FITC]

Flow Cytometry: MCAM/CD146 Antibody (c264) [FITC] [NBP1-28332] - Chicken thymocytes were stained with Mouse Anti-Chicken MCAM-UNLB followed by Goat Anti-Mouse IgG2b, Human ads-PE.
Flow Cytometry: MCAM/CD146 Antibody (c264) [FITC] [NBP1-28332] - Thymocytes from a young chicken were isolated and incubated with purified mouse anti-chicken MCAM MAb. The cells were then stained with goat anti-mouse IgG2b-FITC and analyzed by flow cytometry (BDB, San Jose, CA).

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: MCAM/CD146

Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the third seems to lack transmembrane and cytoplasmic regions. It is highly homologous to gicerin, a molecule involved in neurite outgrowth and Wilm's kidney tumor progression in the chicken, and to the human melanoma progression molecule MUC18. Chicken MCAM is expressed by c-kit+ hematopoietic progenitor cells in embryonic bone marrow, thymocytes, and capillary endothelial cells. MCAM-expressing cells sorted from bone marrow are enriched in progenitors capable of differentiating into T cells when transferred into the appropriate thymic microenvironment. MCAM has been proposed to be involved in cellular adhesion and homing processes. (1)

Long Name

Melanoma Cell Adhesion Molecule

Alternate Names

CD146, L-Gicerin, MUC18

Gene Symbol

MCAM

Additional MCAM/CD146 Products

Product Documents for MCAM/CD146 Antibody (c264) [FITC]

Certificate of Analysis

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Product Specific Notices for MCAM/CD146 Antibody (c264) [FITC]

Protect conjugated forms from light.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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