Melanocortin-1 R/MC1R Antibody (HL1470)

Novus Biologicals | Catalog # NBP3-48655

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Validated by

Knockout/Knockdown, Orthogonal Validation, Independent Antibodies

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # HL1470
View all Melanocortin-1 R/MC1R Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide encompassing a sequence within the Intracellular domain of human Melanocortin-1 R/MC1R. The exact sequence is proprietary.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

35 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Melanocortin-1 R/MC1R Antibody (HL1470)

Melanocortin-1 R/MC1R Antibody (HL1470)

NBP3-48655-Melanocortin-1 R/MC1R Antibody (HL1470)

Various tissue extracts (50 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with MC1 Receptor antibody [HL1470] diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
Melanocortin-1 R/MC1R Antibody (HL1470)

Western Blot: Melanocortin-1 R/MC1R Antibody (HL1470) [NBP3-48655] -

Whole cell extract (30 ug) was separated by 12% SDS-PAGE, and the membranes were blotted with Melanocortin-1 R/MC1R antibody [HL1470] (NBP3-48655) diluted at 1:50000 and competitor's antibody diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

*The competitor is not affiliated with and does not endorse this product.
Melanocortin-1 R/MC1R Antibody (HL1470)

Western Blot: Melanocortin-1 R/MC1R Antibody (HL1470) [NBP3-48655] -

Various whole cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membrane was blotted with Melanocortin-1 R/MC1R antibody [HL1470] (NBP3-48655) diluted at 1:100000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody. Corresponding RNA expression data for the same cell lines are based on Human Protein Atlas program.
Melanocortin-1 R/MC1R Antibody (HL1470)

Western Blot: Melanocortin-1 R/MC1R Antibody (HL1470) [NBP3-48655] -

Various tissue extracts (50 ug) was separated by 12% SDS-PAGE, and the membranes were blotted with Melanocortin-1 R/MC1R antibody [HL1470] (NBP3-48655) diluted at 1:1000 and competitor's antibody (Competitor) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

*The competitor is not affiliated with and does not endorse this product.
Melanocortin-1 R/MC1R Antibody (HL1470)

Western Blot: Melanocortin-1 R/MC1R Antibody (HL1470) [NBP3-48655] -

Non-transfected (-) and transfected (+) unboiled A375 whole cell extracts (30 ug) were separated by 12% SDS-PAGE, and the membranes were blotted with Melanocortin-1 R/MC1R antibody [HL1470] (NBP3-48655) diluted at 1:5000 and competitor's antibody (Highly Cited Competitor) diluted at 1:5000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

*The competitor is not affiliated withand does not endorse this product.

Applications for Melanocortin-1 R/MC1R Antibody (HL1470)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Assay dependent

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Melanocortin-1 R/MC1R

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color. Pheomelanin generates free radicals in response to UV radiation, and elevated levels of pheomelanin have been associated with higher risk of UV-induced skin damage. Therefore, MC1R is a major determinant of sun sensitivity and genetic risk for melanoma and other skin cancers. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.

Long Name

Melanocortin 1 Receptor

Alternate Names

CMM5, MC1R, Melanocortin-1R, Melanocortin1R, MSH-R, Mshra, SHEP2, Tob

Gene Symbol

MC1R

Additional Melanocortin-1 R/MC1R Products

Product Documents for Melanocortin-1 R/MC1R Antibody (HL1470)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Melanocortin-1 R/MC1R Antibody (HL1470)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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