Catalog Number: 1193
Biological Activity
Inhibits Gs and stimulates Gi activity. Inhibits protein kinase C and cAMP-dependent protein kinases. Na+/K+ ATPase inhibitor.
Technical Data
  • M.Wt:
    2847
  • Formula:
    C131H229N39O31
  • Sequence:
    GIGAVLKVLTTGLPALISWIKRKRQQ

    (Modifications: Gln-26 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    20449-79-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Melittin, a metabostatic peptide inhibiting Gs activity.
    Fukushima et al.
    Peptides, 1998;5:811
  2. Membrane interactions of amphiphilic polypeptides mastoparan, melittin, plymixin B and cardiotoxin.
    Raynor et al.
    J.Biol.Chem., 1991;266:2753
  3. G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides.
    Mousli et al.
    TiPS, 1990;11:358
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Melittin include:

1 Citations: Showing 1 - 1

  1. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem 2011;116:984

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