Catalog Number: 1644
Alternate Names: CU-32-085
Chemical Name: N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride
Biological Activity
5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.
Technical Data
  • M.Wt:
    398.95
  • Formula:
    C18H26N4O2S.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    72786-12-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines.
    Marko
    Eur.J.Pharmacol., 1984;101:263
  2. Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors.
    Markstei
    Eur.J.Pharmacol., 1983;95:101
  3. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
    Hoyer et al.
    Pharmacol.Rev., 1994;46:157
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mesulergine hydrochloride include:

1 Citations: Showing 1 - 1

  1. Ergot Alkaloids (Re)generate New Leads as Antiparasitics.
    Authors: Chan Et al.
    Neurotoxicology 2015;9:e0004063

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