Methylmalonate

Key Product Details

Product Description

Methylmalonate is an intracellularly produced malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.

Product Specifications for Methylmalonate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Methylmalonate

The following data is based on the product molecular weight 118.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.47 mL	42.34 mL	84.68 mL
5 mM	1.69 mL	8.47 mL	16.94 mL
10 mM	0.85 mL	4.23 mL	8.47 mL
50 mM	0.17 mL	0.85 mL	1.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• McLaughlin Methylmalonate toxicity in primary neuronal cultures. Neuroscience 1998 PMID: 9692761
• Ehrlich Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease. Neurotherapeutics 2012 PMID: 22441874
• Beal and Ferrante Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat.Rev.Neurosci. 2004 PMID: 15100720

Product Documents for Methylmalonate