Catalog Number: 4979
Chemical Name: 2-Methylpropanedioic acid
Biological Activity
Intracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.
Technical Data
  • M.Wt:
    118.09
  • Formula:
    C4H6O4
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    516-05-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Methylmalonate toxicity in primary neuronal cultures.
    McLaughlin et al.
    Neuroscience, 1998;86:279
  2. Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease.
    Ehrlich
    Neurotherapeutics, 2012;9:270
  3. Experimental therapeutics in transgenic mouse models of Huntington's disease.
    Beal and Ferrante
    Nat.Rev.Neurosci., 2004;5:373

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