Chemical Name: 2-Methylpropanedioic acid
Biological ActivityIntracellularly produces malonate, a reversible succinate dehydrogenase inhibitor used to generate Huntington's disease models. Induces apoptotic cell death in striatal neurons.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Experimental therapeutics in transgenic mouse models of Huntington's disease.
Beal and Ferrante
Methylmalonate toxicity in primary neuronal cultures.
McLaughlin et al.
Huntington's disease and the striatal medium spiny neuron: cell-autonomous and non-cell-autonomous mechanisms of disease.
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