Methylnaltrexone bromide

Key Product Details

Product Description

Methylnaltrexone bromide is a peripherally restricted μ-opioid antagonist. Antagonizes the effects of morphine (Cat. No. 5158) on contraction of isolated guinea pig ileum. Quaternary derivative of naltrexone (Cat. No. 0677).

Product Specifications for Methylnaltrexone bromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Methylnaltrexone bromide

The following data is based on the product molecular weight 436.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.46 mL	22.92 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Valentino Quaternary naltrexone: evidence for the central mediation of discriminative stimulus effects of narcotic agonists and antagonists. J.Pharmacol.Exp.Ther. 1981 PMID: 6262493

Product Documents for Methylnaltrexone bromide