Catalog Number: 3256
Chemical Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemitartrate
Biological Activity
Selective β1-adrenoceptor antagonist (Ki values are 47, 2960 and 10100 nM for β1, β2 and β3 adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Beta-blockers reduce the release and synthesis of endothelin-1 in human endothelial cells.
    Garlichs et al.
    Eur.J.Clin.Invest., 1999;29:12
  2. S-metoprolol: The 2008 Clinical Review.
    Dasbiswas et al.
    J.Indian.Med.Assoc., 2008;106:259
  3. Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells.
    Hoffmann et al.
    Naunyn-Schmied.Arch.Pharmacol., 2004;369:151
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