Chemical Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemitartrate
Biological ActivitySelective β1-adrenoceptor antagonist (Ki values are 47, 2960 and 10100 nM for β1, β2 and β3 adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Beta-blockers reduce the release and synthesis of endothelin-1 in human endothelial cells.
Garlichs et al.
S-metoprolol: The 2008 Clinical Review.
Dasbiswas et al.
Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells.
Hoffmann et al.
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