Metoprolol tartrate

Catalog # Availability Size / Price Qty
3256/50
Metoprolol tartrate | CAS No. 56392-17-7 | Adrenergic beta-1 Receptor Antagonists
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Description: Selective β1 antagonist

Chemical Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemitartrate

Purity: ≥99%

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Biological Activity

Selective β1-adrenoceptor antagonist (Ki values are 47, 2960 and 10100 nM for β1, β2 and β3 adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo.

Technical Data

M.Wt:
342.4
Formula:
C15H25NO3.½C4H6O6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
56392-17-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Beta-blockers reduce the release and synthesis of endothelin-1 in human endothelial cells.
    Garlichs et al.
    Eur.J.Clin.Invest., 1999;29:12
  2. S-metoprolol: The 2008 Clinical Review.
    Dasbiswas et al.
    J.Indian.Med.Assoc., 2008;106:259
  3. Comparative pharmacology of human β-adrenergic receptor subtypes - characterization of stably transfected receptors in CHO cells.
    Hoffmann et al.
    Naunyn-Schmied.Arch.Pharmacol., 2004;369:151

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