Chemical Name: N-[2-[[6-Chloro-3-[3-[(dimethylamino)sulfonyl]phenyl]-2-methylimidazo[1,2-b]pyridazin-8-yl]amino]ethyl]acetamide
Biological ActivityMI 14 is a potent and selective PI 4-K IIIβ inhibitor (IC50 = 54 nM). Exhibits >1,800-fold selectivity for PI 4-K IIIβ over PI 4-K IIIα and PI 4-K IIα, respectively. Exhibits antiviral activity against single-stranded positive sense RNA viruses in HeLa cell-based assays.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Highly selective phosphatidylinositol 4-kinase IIIβ inhibitors and structural insight into their mode of action.
Mejdrová et al.
Citation for MI 14
The citations listed below are publications that use Tocris products. Selected citations for MI 14 include:
1 Citation: Showing 1 - 1
Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist.
Authors: Wooree Et al.
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