MI 2 (MALT1 inhibitor)
Chemical Name: 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
Biological ActivityMALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.
Fontan et al.
Cancer Cell, 2012;22:812
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for MI 2 (MALT1 inhibitor)
There are currently no reviews for this product. Be the first to review MI 2 (MALT1 inhibitor) and earn rewards!
Have you used MI 2 (MALT1 inhibitor)?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image