MI 2 (MALT1 inhibitor)

Tocris Bioscience | Catalog # 4848

MALT1 inhibitor
Tocris Bioscience

Key Product Details

Description

MALT1 inhibitor
View all Additional Synthetic Protease Inhibitors »

Product Description

MI 2 (MALT1 inhibitor) is a MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.

Product Specifications for MI 2 (MALT1 inhibitor)

Molecular Weight

455.72

Formula

C19H17Cl3N4O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide

CAS Number

1047953-91-2

PubChem ID

45942672

InChI Key

TWJGQZBSEMDPQP-UHFFFAOYSA-N

SMILES

O=C(CCl)NC(C=C3)=CC=C3N1C(C2=CC(Cl)=C(Cl)C=C2)=NC(OCCOC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.57 100
Ethanol 9.11 20

Preparing Stock Solutions for MI 2 (MALT1 inhibitor)

The following data is based on the product molecular weight 455.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.97 mL 21.94 mL
5 mM 0.44 mL 2.19 mL 4.39 mL
10 mM 0.22 mL 1.10 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for MI 2 (MALT1 inhibitor)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MI 2 (MALT1 inhibitor)

For research use only

Citations for MI 2 (MALT1 inhibitor)

Customer Reviews for MI 2 (MALT1 inhibitor) (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used MI 2 (MALT1 inhibitor)?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • A MALT1 Protease Inhibitor that works really well
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MDA231, U2OS
    Verified Customer | Posted 12/08/2019
    MALT1 protease inhibitor MI-2 suppress RelB cleavage in a dose-dependent manner in U2OS osteosarcoma cells. Cells were pretreated with increasing concentration of MI2 inhibitor (0.25, 0.5, 1, or 2 µM) for 1 h prior to stimulation with 2 U/mL thrombin for an additional 3 h. MDA-MB-231 cells stimulated with thrombin also show evidence of RelB cleavage that is suppressed by MI-2 (2 μM).
    MI 2 (MALT1 inhibitor) 4848

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All