MI 2 (MALT1 inhibitor)
Chemical Name: 2-Chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1,2,4-triazol-1-yl]phenylacetamide
Biological ActivityMALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.
Fontan et al.
Cancer Cell, 2012;22:812
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MALT1 protease inhibitor MI-2 suppress RelB cleavage in a dose-dependent manner in U2OS osteosarcoma cells. Cells were pretreated with increasing concentration of MI2 inhibitor (0.25, 0.5, 1, or 2 µM) for 1 h prior to stimulation with 2 U/mL thrombin for an additional 3 h. MDA-MB-231 cells stimulated with thrombin also show evidence of RelB cleavage that is suppressed by MI-2 (2 μM).