Catalog Number: 3117
Alternate Names: N-Butyldeoxynojirimycin hydrochloride, NB-DNJ
Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Biological Activity
Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Deuterated analog also available.

Technical Data
  • M.Wt:
    255.74
  • Formula:
    C10H21NO4.HCl
  • Solubility:
    Soluble to 75 mM in water and to 75 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    210110-90-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.
    Platt et al.
    J.Biol.Chem., 1994;269:8362
  2. Targeting glycosylation as a therapeutic approach.
    Dwek et al.
    Nat.Rev.Drug Disc., 2002;1:65
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Miglustat hydrochloride include:

1 Citations: Showing 1 - 1

  1. Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis.
    Authors: Huang Et al.
    FASEB J 2011;25:3661
Tocris Small Molecules
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Miglustat - d9 hydrochloride

5539  
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