Miglustat hydrochloride

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3117/10
Miglustat hydrochloride | CAS No. 210110-90-0 | Glycosylase Inhibitors
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Description: α-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases
Alternative Names: N-Butyldeoxynojirimycin hydrochloride, NB-DNJ

Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride

Product Details
Citations (1)
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Biological Activity

Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Deuterated analog also available.

Technical Data

M.Wt:
255.74
Formula:
C10H21NO4.HCl
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
210110-90-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.
    Platt et al.
    J.Biol.Chem., 1994;269:8362
  2. Targeting glycosylation as a therapeutic approach.
    Dwek et al.
    Nat.Rev.Drug Disc., 2002;1:65
  3. Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.
    Noel et al.
    J.Pharamcol.Exp.Ther., 2008;325:1016

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Citation for Miglustat hydrochloride

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