Miglustat hydrochloride

Key Product Details

Product Description

Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Product Specifications for Miglustat hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Miglustat hydrochloride

The following data is based on the product molecular weight 255.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	5.21 mL	26.07 mL	52.14 mL
3.75 mM	1.04 mL	5.21 mL	10.43 mL
7.5 mM	0.52 mL	2.61 mL	5.21 mL
37.5 mM	0.10 mL	0.52 mL	1.04 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dwek Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 2002 PMID: 12119611
• Noel Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharmacol.Exp.Ther. 2008 PMID: 18309088
• Platt N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 1994 PMID: 8132559

Product Documents for Miglustat hydrochloride