Mirabegron

Catalog # Availability Size / Price Qty
7070/5
7070/25
Mirabegron | CAS No. 223673-61-8 | Adrenergic beta-3 Receptor Agonists
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Description: Potent and selective β3 agonist

Chemical Name: 2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective β3-adrenoceptor agonist (EC50 = 22.4 nM). Displays >440-fold selectivity for β3 over β1 and β2 adrenoceptors. Increases cAMP concentration in CHO cells expressing human β3-adrenoceptor. Displays relaxant effect in ex vivo rat bladder muscle preparation precontracted with carbachol (Cat. No. 2810). Decreases frequency of bladder contraction in rats. Also promotes browning of white adipose tissue, reduces body weight, and improves glucose tolerance and insulin sensitivity in mice fed a high fat diet.

Technical Data

M.Wt:
396.51
Formula:
C21H24N4O2S
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
223673-61-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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