Catalog Number: 3190
Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Biological Activity
Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule versus DNA repair mechanisms.
    Nat.Chem.Biol., 2008;4:86
  2. Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.
    Garner et al.
    Nat.Chem.Biol., 2009;5:129
  3. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
    Dupre et al.
    Nat.Chem.Biol., 2008;4:119

The citations listed below are publications that use Tocris products. Selected citations for Mirin include:

Showing Results 1 - 2 of 2

  1. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression
    Authors: Hampp Et al.
    Proc Natl Acad Sci U S A.
  2. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
    Authors: Bothmer Et al.
    Regul Pept
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