Mirin

  ( 3 citations )    
Product Datasheet
Catalog Number:3190
Chemical Name:Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Product Details
Citations (3)
Reviews
Biological Activity
Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.
Technical Data
  • M.Wt:
    220.25
  • Formula:
    C10H8N2O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    1198097-97-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mirin include:

3 Citations: Showing 1 - 3
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  1. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression
    Authors: Hampp Et al.
    Proc Natl Acad Sci U S A.  2016;113:E4311
  2. The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.
    Authors: Lee and Dunphy
    Mol Biol Cell  2013;24:1343
  3. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
    Authors: Bothmer Et al.
    Regul Pept  2013;210:115

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