Catalog Number: 3190
Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Biological Activity
Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.
Technical Data
  • M.Wt:
    220.25
  • Formula:
    C10H8N2O2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    1198097-97-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small molecule versus DNA repair mechanisms.
    Stivers
    Nat.Chem.Biol., 2008;4:86
  2. Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.
    Garner et al.
    Nat.Chem.Biol., 2009;5:129
  3. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
    Dupre et al.
    Nat.Chem.Biol., 2008;4:119
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mirin include:

2 Citations: Showing 1 - 2
Filter your results:

  1. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression
    Authors: Hampp Et al.
    Proc Natl Acad Sci U S A. 2016;113:E4311
  2. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
    Authors: Bothmer Et al.
    Regul Pept 2013;210:115

Have you used Mirin?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information