Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one
Biological ActivityMre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
Dupre et al.
Small molecule versus DNA repair mechanisms.
Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.
Garner et al.
Citations for Mirin
The citations listed below are publications that use Tocris products. Selected citations for Mirin include:
5 Citations: Showing 1 - 5
Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
Authors: Hollingworth Et al.
J Virol 2017;91
Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs.
Authors: Berte Et al.
Mol Cancer Ther 2016;15:2665
DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression
Authors: Hampp Et al.
Proc Natl Acad Sci U S A. 2016;113:E4311
The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks.
Authors: Lee and Dunphy
Mol Biol Cell 2013;24:1343
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
Authors: Bothmer Et al.
Regul Pept 2013;210:115
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