Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50
= 12 μ
M) and induces G2
cell cycle arrest. Also blocks homology-directed repair in vitro
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Small molecule versus DNA repair mechanisms.
Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.
Garner et al.
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.
Dupre et al.
The citations listed below are publications that use Tocris products. Selected citations for Mirin include:
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