11 results for "Checkpoint Control Kinase Inhibitors" in Products
Checkpoint Control Kinase Inhibitors
Checkpoint control kinases is a term used to describe a group of enzymes that regulate progression of a cell through the cell cycle. Catastrophic genetic damage can occur if cells progress to the next phase of the cell cycle before the previous phase is properly completed. Checkpoint control kinases function to halt the cell cycle at these critical points. Examples of checkpoint control kinases include ATM, ATR, DNA-PK, Chk1, Chk2, Wee1 and mTOR.
For a cell to progress through the cycle and ...
Potent and selective ATM kinase inhibitor
| Chemical Name: | 2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one |
| Purity: | ≥98% |
Potent and selective DNA-PK inhibitor
| Alternate Names: | KU 57788 |
| Chemical Name: | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% |
Inhibitor of PI 3-kinase, mTOR and DNA-PK
| Chemical Name: | 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride |
| Purity: | ≥98% |
Chk1 inhibitor
| Chemical Name: | 9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione |
| Purity: | ≥98% |
Potent and selective inhibitor of Chk1 and Wee1
| Chemical Name: | 9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione |
| Purity: | ≥98% |
Potent Src inhibitor; also inhibits FGFR1, PDGFRβ and Wee1
| Chemical Name: | 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride |
| Purity: | ≥98% |
Potent and selective Mps1 kinase inhibitor
| Chemical Name: | 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one |
| Purity: | ≥98% |
Cdk inhibitor; potently inhibits cdk9; also inhibits MK2
| Chemical Name: | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride |
| Purity: | ≥98% |
MRN-ATM pathway inhibitor
| Chemical Name: | Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one |
| Purity: | ≥98% |
Potent and selective BUB1 kinase inhibitor
| Chemical Name: | 2-[3,5-Difluoro-4-[[3-[5-methoxy-4-[(3-methoxy-4-pyridinyl)amino]-2-pyrimidinyl]-1H-indazol-1-yl]methyl]phenoxy]ethanol |
| Purity: | ≥98% |
Potent and selective Wee1 inhibitor
| Alternate Names: | AZD 1775,MK 1775 |
| Chemical Name: | 1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one |
| Purity: | ≥98% |
