Mirtazapine

  ( 2 citations )    
Product Datasheet
Catalog Number:2018
Alternate Names:Org 3770, 6-Azamianserin
Chemical Name:1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Product Details
Citations (2)
Reviews
Biological Activity
Antidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist (pKi values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pKi values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.
Technical Data
  • M.Wt:
    265.36
  • Formula:
    C17H19N3
  • Solubility:
    Soluble to 50 mM in ethanol and to 20 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    85650-52-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mirtazapine include:

2 Citations: Showing 1 - 2
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  1. Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
    Authors: Otvos Et al.
    Cancer Res  2015;7:2336
  2. Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
    Authors: Midkiff Et al.
    PLoS One  2011;6:e25395

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