Mirtazapine

Catalog # Availability Size / Price Qty
2018/10
2018/50
Mirtazapine | CAS No. 85650-52-8 | Non-selective 5-HT2 Receptor Antagonists
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Description: Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant
Alternative Names: Org 3770, 6-Azamianserin

Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

Purity: ≥99%

Product Details
Citations (2)
Reviews

Biological Activity

Antidepressant agent; potent 5-HT2, 5-HT3 and histamine H1 receptor antagonist and moderately potent α2-adrenoceptor antagonist (pKi values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pKi values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo.

Technical Data

M.Wt:
265.36
Formula:
C17H19N3
Solubility:
Soluble to 50 mM in ethanol and to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
85650-52-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Mirtazapine

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