Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+
, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
Soluble to 50 mM in DMSO
Desiccate at -20°C
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Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
Demicheli and Garnier-Suillerot
Mithramycin selectively inhibits transcription of G-C containing DNA.
Miller et al.
Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.
Ray et al.
The citations listed below are publications that use Tocris products. Selected citations for Mithramycin A include:
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