Mithramycin A

Catalog # Availability Size / Price Qty
1489/1
Mithramycin A | CAS No. 18378-89-7 | RNA/DNA Polymerase Inhibitors
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Description: Inhibitor of DNA and RNA polymerase

Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose

Purity: ≥95%

Product Details
Citations (6)
Reviews (1)

Biological Activity

Mithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

Technical Data

M.Wt:
1085.16
Formula:
C52H76O24
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
18378-89-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
    Demicheli and Garnier-Suillerot
    Biochem.Biophys.Res.Commun., 1991;177:511
  2. Mithramycin selectively inhibits transcription of G-C containing DNA.
    Miller et al.
    Am.J.Med.Sci., 1987;294:388
  3. Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.
    Ray et al.
    Am.J.Med.Sci., 1990;300:203

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⚠ WARNING: This product can expose you to chemicals including Plicamycin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Mithramycin A

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Mithramycin A completely kills melanoma cell line at micromolar concentrations
By Anonymous on 02/07/2019
Application: Species: Human

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).


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