Catalog Number: 1489
Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6
Biological Activity
Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
    Demicheli and Garnier-Suillerot
    Biochem.Biophys.Res.Commun., 1991;177:511
  2. Mithramycin selectively inhibits transcription of G-C containing DNA.
    Miller et al.
    Am.J.Med.Sci., 1987;294:388
  3. Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.
    Ray et al.
    Am.J.Med.Sci., 1990;300:203
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