Catalog Number: 1489
Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6
Biological Activity
Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
Technical Data
  • M.Wt:
    1085.16
  • Formula:
    C52H76O24
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    18378-89-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
    Demicheli and Garnier-Suillerot
    Biochem.Biophys.Res.Commun., 1991;177:511
  2. Mithramycin selectively inhibits transcription of G-C containing DNA.
    Miller et al.
    Am.J.Med.Sci., 1987;294:388
  3. Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.
    Ray et al.
    Am.J.Med.Sci., 1990;300:203
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mithramycin A include:

5 Citations: Showing 1 - 5
Filter your results:

  1. Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.
    Authors: Oh Et al.
    J Neurosci 2015;6:e1750
  2. Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.
    Authors: Siddesha Et al.
    J Cell Physiol 2014;229:845
  3. Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression.
    Authors: Huang Et al.
    FASEB J 2012;26:3703
  4. Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes.
    Authors: Corsini Et al.
    Gene Regul Syst Bio 2007;1:207
  5. The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).
    Authors: Duverger Et al.
    Cell Death Dis 2004;90:2025

Have you used Mithramycin A?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information