Mithramycin A

  ( 6 citations )    
Product Datasheet
Catalog Number:1489
Chemical Name:(1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6
Product Details
Citations (6)
Reviews
Biological Activity
Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
Technical Data
  • M.Wt:
    1085.16
  • Formula:
    C52H76O24
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >95
  • Storage:
    Desiccate at -20°C
  • CAS No:
    18378-89-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Mithramycin A include:

6 Citations: Showing 1 - 6
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  1. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
    Authors: Huang Et al.
    Cell Res  2016;26:1112
  2. Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.
    Authors: Oh Et al.
    J Neurosci  2015;6:e1750
  3. Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.
    Authors: Siddesha Et al.
    J Cell Physiol  2014;229:845
  4. Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression.
    Authors: Huang Et al.
    FASEB J  2012;26:3703
  5. Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes.
    Authors: Corsini Et al.
    Gene Regul Syst Bio  2007;1:207
  6. The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).
    Authors: Duverger Et al.
    Cell Death Dis  2004;90:2025

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