Chemical Name: (1S)-5-Deoxy-1-C-[(2S,3S)-7-[[2,6-dideoxy-3-O-(2,6-dideoxy-β-D-arabino-hexopyranosyl)-β-D-arabino-hexopyranosyl]oxy]-3-[(O-2,6-dideoxy-3-C-methyl-β-D-ribo-hexopyranosyl-(1.fwdarw.3)-O-2,6-dideoxy-β-D-lyxo-hexopyranosyl-(1.fwdarw.3)-2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-1-O-methyl-D-threo-2-pentulose
Biological ActivityMithramycin A is an anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg2+ or Zn2+, inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Mithramycin cannot bind to left-handed poly(dG-m5dC) in the presence of Mg2+ ion.
Demicheli and Garnier-Suillerot
Mithramycin selectively inhibits transcription of G-C containing DNA.
Miller et al.
Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene.
Ray et al.
Citations for Mithramycin A
The citations listed below are publications that use Tocris products. Selected citations for Mithramycin A include:
6 Citations: Showing 1 - 6
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress.
Authors: Huang Et al.
Cell Res 2016;26:1112
Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.
Authors: Oh Et al.
J Neurosci 2015;6:e1750
Acetylsalicylic acid inhibits IL-18-induced cardiac fibroblast migration through the induction of RECK.
Authors: Siddesha Et al.
J Cell Physiol 2014;229:845
Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression.
Authors: Huang Et al.
FASEB J 2012;26:3703
Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes.
Authors: Corsini Et al.
Gene Regul Syst Bio 2007;1:207
The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).
Authors: Duverger Et al.
Cell Death Dis 2004;90:2025
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Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).