MitMAB

Catalog #: 4224 Datasheet / COA / SDS

Discontinued Product

4224 has been discontinued.
View all Dynamin Inhibitors products.
MitMAB | CAS No. 1119-97-7 | Dynamin Inhibitors
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Description: Dynamin inhibitor

Chemical Name: Tetradecyltrimethylammonium bromide

Product Details
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Biological Activity

MitMAB is a dynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Targets the dynamin-phospholipid interaction. Inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Displays dynamin I-inhibitory activity similar to OctMAB (Cat. No. 4225).

Technical Data

M.Wt:
336.39
Formula:
C17H38BrN
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
1119-97-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity.
    Hill et al.
    Bioorg.Med.Chem.Lett., 2004;14:3275
  2. Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.
    Quan et al.
    Mol.Pharmacol., 2007;72:1425
  3. Endocytosis is required for E-cadherin redistribution at mature adherens junctions.
    de Beco et al.
    Proc.Natl.Acad.Sci., 2009;106:7010

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