Dynamin inhibitor (IC50
= 1.9 μ
M for dynamin I). Inhibits receptor-mediated endocytosis (IC50
= 16 μ
M). Displays similar activity to MitMAB
(Cat. No. 4224).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.
Quan et al.
The dynamin inhibitors MitMAB and OctMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.
Joshi et al.
Mol.Cancer Ther., 2010;9:1995