OctMAB
Chemical Name: Octadecyltrimethylammonium bromide
Biological Activity
OctMAB is a dynamin inhibitor (IC50 = 1.9 μM for dynamin I). Inhibits receptor-mediated endocytosis (IC50 = 16 μM). Displays similar activity to MitMAB (Cat. No. 4224).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Endophilin marks and controls a clathrin-independent endocytic pathway.
Boucrot E, Ferreira A, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon H
Nature, 2015;517(7535):460-5. -
Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II.
Quan et al.
Mol.Pharmacol., 2007;72:1425 -
The dynamin inhibitors MitMAB and OctMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.
Joshi et al.
Mol.Cancer Ther., 2010;9:1995
Product Datasheets
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Citation for OctMAB
The citations listed below are publications that use Tocris products. Selected citations for OctMAB include:
1 Citation: Showing 1 - 1
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Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
Authors: Ford Et al.
PLoS Pathog 2018;14:e1007051
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