Mitofusin 1 Antibody (S05-3A8)

Novus Biologicals | Catalog # NBP3-19890

Recombinant Monoclonal Antibody
Novus Biologicals
100% Guarantee

Key Product Details

Species Reactivity

Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S05-3A8 expressed in HEK293
View all Mitofusin 1 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of mouse Mitofusin 1 (Uniprot # Q8R4Z9)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Mitofusin 1 Antibody (S05-3A8)

Western Blot: Mitofusin 1 Antibody (S05-3A8) [NBP3-19890]

Western Blot: Mitofusin 1 Antibody (S05-3A8) [NBP3-19890]

Western Blot: Mitofusin 1 Antibody (S05-3A8) [NBP3-19890] - Western blot detection of Mitofusin 1 in CHO-K1, C6 cell lysates using NBP3-19890 (1:1000 diluted). Predicted band size: 84kDa. Observed band size: 84kDa.

Applications for Mitofusin 1 Antibody (S05-3A8)

Application
Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Mitofusin 1

MFN1 (Mitofusin-1) is a nuclear encoded mitochondrial membrane protein that mediates mitochondrial fusion and morphology in mammalian cells. MFN1 and MFN2 are homologs of the Drosophila protein Fuzzy Onion (Fzo) that interact with each other to facilitate mitochondrial targeting. MFN1 is ubiquitously expressed,with slightly higher leves detectedl in kidney and heart. MFN2 may be overexpressed in some tumors, such as lung cancers.

Mitochondrial fusion occurs in many cell types and is a fundamental component of mitochondria morphology, which is balanced between fusion and fission. Mitochondrial dysfunction is a major cause of neuronal death in degenerative disorders, such as Parkinson's disease, and can be triggered by an imbalance in the dynamic equilibrium between mitochondrial fission and fusion.

Alternate Names

hfzo1, hfzo2, MFN1

Gene Symbol

MFN1

Additional Mitofusin 1 Products

Product Documents for Mitofusin 1 Antibody (S05-3A8)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

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Product Specific Notices for Mitofusin 1 Antibody (S05-3A8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Bcl-2 Proteins and Regulators

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