Chemical Name: [4-[4-[3-Oxo-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide
Biological ActivityFluorescent probe for imaging hydrogen peroxide (H2O2) in mitochondria of living cells. Displays enhanced emission at 528 nm in the presence of H2O2. Selective for H2O2 over superoxide, nitric oxide and hydroxyl radical. Detects local increases in H2O2 in an in vitro model of Parkinson's Disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes.
Guo et al.
A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells.
Dickinson and Chang
Lighting up H2O2: the molecule that is a "necessary evil" in the cell.
Citations for MitoPY1
The citations listed below are publications that use Tocris products. Selected citations for MitoPY1 include:
5 Citations: Showing 1 - 5
Real-time fluorescence measurements of ROS and [Ca2+} in ischemic/reperfused rat hearts: detectable increases occur only after mitochondrial pore opening and are attenuated by ischaemic preconditioning.
Authors: Andrienko Et al.
PLoS One. 2016;11:e0167300
Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.
Authors: Camaré Et al.
Br J Pharmacol 2015;172:106
Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.
Authors: Griffith Et al.
Cell Rep 2015;12:1071
An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.
Authors: Beyer Et al.
Am J Physiol Heart Circ Physiol 2014;307:H1587
Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.
Authors: Freed Et al.
Circ Res 2014;115:525
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