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MitoPY1

Catalog #: 4428
10 Citations Datasheet / COA / SDS
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4428/10
MitoPY1 | CAS No. 1041634-69-8 | Fluorescent Cell Indicators and Sensors
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Description: Fluorescent mitochondrial hydrogen peroxide indicator

Chemical Name: [4-[4-[3-Oxo-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

MitoPY1 is a fluorescent probe for imaging hydrogen peroxide (H2O2) in mitochondria of living cells. Displays enhanced emission at 528 nm in the presence of H2O2. Selective for H2O2 over superoxide, nitric oxide and hydroxyl radical. Detects local increases in H2O2 in an in vitro model of Parkinson's Disease.

Technical Data

M.Wt:
954.68
Formula:
C52H53BIN2O5P
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
1041634-69-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the Regents of the University of California

Product Datasheets

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Citations for MitoPY1

The citations listed below are publications that use Tocris products. Selected citations for MitoPY1 include:

10 Citations: Showing 1 - 10

  1. Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells.
    Authors: Moreira Et al.
    Oxid Med Cell Longev  2019;2019:6793957
  2. CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation.
    Authors: Karunakaran Et al.
    Free Radic.Biol.Med.  2019;134:505
  3. Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.
    Authors: Zlatic Et al.
    Cell Syst  2018;6:368
  4. Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.
    Authors: Abuaita Et al.
    Cell Host Microbe  2018;24:625
  5. Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
    Authors: Zhang Et al.
    Sci Signal  2018;11
  6. Real-time fluorescence measurements of ROS and [Ca2+} in ischemic/reperfused rat hearts: detectable increases occur only after mitochondrial pore opening and are attenuated by ischaemic preconditioning.
    Authors: Andrienko Et al.
    PLoS One.  2016;11:e0167300
  7. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.
    Authors: Camaré Et al.
    Br J Pharmacol  2015;172:106
  8. Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.
    Authors: Griffith Et al.
    Cell Rep  2015;12:1071
  9. An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.
    Authors: Beyer Et al.
    Am J Physiol Heart Circ Physiol  2014;307:H1587
  10. Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.
    Authors: Freed Et al.
    Circ Res  2014;115:525

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