Catalog Number: 4428
Chemical Name: [4-[4-[3-Oxo-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide
Biological Activity
Fluorescent probe for imaging hydrogen peroxide (H2O2) in mitochondria of living cells. Displays enhanced emission at 528 nm in the presence of H2O2. Selective for H2O2 over superoxide, nitric oxide and hydroxyl radical. Detects local increases in H2O2 in an in vitro model of Parkinson's Disease.
Technical Data
  • M.Wt:
    954.68
  • Formula:
    C52H53BIN2O5P
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    1041634-69-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from the Regents of the University of California
Background References
  1. Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes.
    Guo et al.
    J.Biomed.Opt., 2013;18
  2. A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells.
    Dickinson and Chang
    J.Am.Chem.Soc., 2008;130:9638
  3. Lighting up H2O2: the molecule that is a "necessary evil" in the cell.
    Zhao
    Angew.Chem.Int.Ed.Engl., 2009;48:3022
Citations:

The citations listed below are publications that use Tocris products. Selected citations for MitoPY1 include:

1 Citations: Showing 1 - 1

  1. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.
    Authors: Camaré Et al.
    Br J Pharmacol 2015;172:106

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