Chemical Name: [4-[4-[3-Oxo-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3'-yl]-1-piperazinyl]butyl]triphenyl-phosphonium iodide
Biological ActivityMitoPY1 is a fluorescent probe for imaging hydrogen peroxide (H2O2) in mitochondria of living cells. Displays enhanced emission at 528 nm in the presence of H2O2. Selective for H2O2 over superoxide, nitric oxide and hydroxyl radical. Detects local increases in H2O2 in an in vitro model of Parkinson's Disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes.
Guo et al.
A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells.
Dickinson and Chang
Lighting up H2O2: the molecule that is a "necessary evil" in the cell.
Citations for MitoPY1
The citations listed below are publications that use Tocris products. Selected citations for MitoPY1 include:
10 Citations: Showing 1 - 10
Prooxidative Activity of Celastrol Induces Apoptosis, DNA Damage, and Cell Cycle Arrest in Drug-Resistant Human Colon Cancer Cells.
Authors: Moreira Et al.
Oxid Med Cell Longev 2019;2019:6793957
CD36 dependent redoxosomes promotes ceramide-mediated pancreatic β-cell failure via p66Shc activation.
Authors: Karunakaran Et al.
Free Radic.Biol.Med. 2019;134:505
Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.
Authors: Zlatic Et al.
Cell Syst 2018;6:368
Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.
Authors: Abuaita Et al.
Cell Host Microbe 2018;24:625
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
Authors: Zhang Et al.
Sci Signal 2018;11
Real-time fluorescence measurements of ROS and [Ca2+} in ischemic/reperfused rat hearts: detectable increases occur only after mitochondrial pore opening and are attenuated by ischaemic preconditioning.
Authors: Andrienko Et al.
PLoS One. 2016;11:e0167300
Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody.
Authors: Camaré Et al.
Br J Pharmacol 2015;172:106
Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.
Authors: Griffith Et al.
Cell Rep 2015;12:1071
An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles.
Authors: Beyer Et al.
Am J Physiol Heart Circ Physiol 2014;307:H1587
Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.
Authors: Freed Et al.
Circ Res 2014;115:525
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Cells were incubated in the well with 8 μg/ml MitoPy diluted in PBS