Potent and selective CB1
receptor antagonist (Ki
= 27.2 pM, IC50
= 118.9 pM for rat CB1
receptors). Exhibits potency in obesity and hyperlipidemia models; inhibits food intake and increases in body weight in diet-induced obese rats and mice.
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Novel, selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models.
Chen et al.
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