Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinylmethyl)-1H-pyrazole-3-carboxamide
Biological ActivityMJ 15 is a potent and selective CB1 receptor antagonist (Ki = 27.2 pM, IC50 = 118.9 pM for rat CB1 receptors). Exhibits potency in obesity and hyperlipidemia models; inhibits food intake and increases in body weight in diet-induced obese rats and mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel, selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models.
Chen et al.
Citations for MJ 15
The citations listed below are publications that use Tocris products. Selected citations for MJ 15 include:
2 Citations: Showing 1 - 2
Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons.
Authors: Tan and Cao
Int J Mol Med 2018;42:919
Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1.
Authors: Kong Et al.
J Virol 2016;13:4569
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