MK 1903

Key Product Details

Product Description

MK 1903 is a potent and selective hydroxycarboxylic acid receptor 2 (HCA₂, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC₅₀ values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.

Product Specifications for MK 1903

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MK 1903

The following data is based on the product molecular weight 164.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.09 mL	30.46 mL	60.92 mL
5 mM	1.22 mL	6.09 mL	12.18 mL
10 mM	0.61 mL	3.05 mL	6.09 mL
50 mM	0.12 mL	0.61 mL	1.22 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Lauring Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. Sci.Transl.Med. 2012 PMID: 22914621
• Boatman (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[α]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J.Med.Chem. 2012 PMID: 22435740

Product Documents for MK 1903