Chemical Name: (4aR,5aR)-4,4a,5,5a-Tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2]pyrazole-3-carboxylic acid
Biological ActivityPotent and selective hydroxycarboxylic acid receptor 2 (HCA2, GPR109A) full agonist; exhibits greater potency than niacin in a whole cell HTRF-cAMP assay (EC50 values are 12.9 and 51 nM respectively). Exhibits no binding at the GRP109B receptor.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[α]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans.
Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.
Citations for MK 1903
The citations listed below are publications that use Tocris products. Selected citations for MK 1903 include:
2 Citations: Showing 1 - 2
Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells
Authors: Marinelli Et al.
Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
Authors: Martin-Gallausiaux Et al.
Front Immunol 2019;9:2838
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