MK 2206 dihydrochloride

Key Product Details

Product Description

MK 2206 dihydrochloride is a potent and selective allosteric Akt inhibitor (IC₅₀ values are 5 nM, 12 nM, and 65 nM for Akt1, Akt2, and Akt3, respectively). MK 2206 requires the Pleckstrin homology domain for its activity, and exhibits no inhibitory activity in a panel of 250 tested protein kinases. MK 2206 induces growth inhibition of different cancer cell lines (IC₅₀ in the range 3.4 and 28.6 μmol/L) and enhances antitumor efficacy of a range of standard chemotherapeutics. It synergistically inhibits cell proliferation of human lung and breast cancer cells in combination with Erlotinib (Cat. No. 7194) by suppressing both the Ras/Erk and PI 3-K pathways in vitro and in vivo. MK 2206 can be used to block the IL-22 - Akt signaling pathway for studying paneth cell differentiation.

Product Specifications for MK 2206 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MK 2206 dihydrochloride

The following data is based on the product molecular weight 480.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.16 mL	20.82 mL	41.63 mL
2.5 mM	0.83 mL	4.16 mL	8.33 mL
5 mM	0.42 mL	2.08 mL	4.16 mL
25 mM	0.08 mL	0.42 mL	0.83 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Hirai MK-2206, an allosteric Akt Inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol.Cancer Ther. 2010 PMID: 20571069
• Li Abstract #DDT01-1: MK-2206: A potent oral allosteric AKT inhibitor. AACR Annual Meeting
• He Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation. Cell Stem Cell 2022 PMID: 36002022

Product Documents for MK 2206 dihydrochloride