ML 277

Catalog # Availability Size / Price Qty
4777/10
4777/50
Voltage-gated Potassium Channel Activators Small Molecule
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Description: Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current

Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Selective K v 7.1 (KCNQ1) potassium channel activator (EC 50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments I Ks current of cultured human cardiomyocytes and shortens action potential duration.

Technical Data

M.Wt:
471.59
Formula:
C23H25N3O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1401242-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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ML 277 is a good voltage gated K+ channel activator
By Anonymous on 10/23/2018
Species: Human

ML 277 is being used on our lab for its selective channel activation properties. It shows great Kv channel opening properties. Have been used in published papers and the data produced are consistent.


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