ML 277

Catalog # Availability Size / Price Qty
4777/10
4777/50
Cat.No. 4777 - ML 277 | C23H25N3O4S2 | CAS No. 1401242-74-7
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Description: Selective Kv7.1 (KCNQ1) potassium channel activator; augments IKs current

Chemical Name: (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide

Purity: ≥98%

Product Details
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Biological Activity

Selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.

Technical Data

M.Wt:
471.59
Formula:
C23H25N3O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1401242-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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