ML 277

Tocris Bioscience | Catalog # 4777

Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
Tocris Bioscience

Key Product Details

Description

Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
View all Voltage-gated Potassium Channel Activators »

Product Description

ML 277 is a selective Kv7.1 (KCNQ1) potassium channel activator (EC50 = 260 nM). Exhibits >100-fold selectivity versus KCNQ2, KCNQ4 and hERG potassium channels. Augments IKs current of cultured human cardiomyocytes and shortens action potential duration.

Product Specifications for ML 277

Molecular Weight

471.59

Formula

C23H25N3O4S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide

CAS Number

1401242-74-7

PubChem ID

53347902

InChI Key

OXQNLLVUVDAEHC-OAQYLSRUSA-N

SMILES

O=[C@@]([C@H]3CCCCN3S(C4=CC=C(C)C=C4)(=O)=O)NC1=NC(C2=CC=C(OC)C=C2)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.16 100

Preparing Stock Solutions for ML 277

The following data is based on the product molecular weight 471.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.60 mL 21.20 mL
5 mM 0.42 mL 2.12 mL 4.24 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for ML 277

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 277

For research use only

Customer Reviews for ML 277 (1)

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  • ML 277 is a good voltage gated K+ channel activator
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/23/2018
    Dissolve in DMSO. For sterile conditions, use sterile DMSO.
    ML 277 is being used on our lab for its selective channel activation properties. It shows great Kv channel opening properties. Have been used in published papers and the data produced are consistent.
    ML 277 4777

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