ML 297

Catalog # Availability Size / Price Qty
5380/10
5380/50
ML 297 | CAS No. 1443246-62-5 | Inward Rectifier Potassium Channel Activators
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Description: Selective Kir3.1/3.2 (GIRK1/2) channel activator

Chemical Name: N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.

Technical Data

M.Wt:
328.32
Formula:
C17H14F2N4O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
1443246-62-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Vanderbilt University

Product Datasheets

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ML 297 worked ideally and the data obtained with the product was consistent throughout the study
By Anonymous on 10/31/2018
Application: Species: Human

ML 297 and ML 277 was used on our University labs to understand potassium channel activation percentage at increasing concentrations. ML 297 worked ideally and the data obtained with the product was consistent throughout the experiment.


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