Chemical Name: 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide
Biological ActivityML 299 is a selective allosteric modulator and potent inhibitor of phospholipases D1 and D2 (IC50 values are 6 and 12 nM, respectively). ML 299 decreases invasive migration in glioblastoma cells and increases caspase 3/7 activity in serum-free conditions. ML 299 is non-cytotoxic, active in vivo and CNS penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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