Potent and selective hCXCR6 antagonist (IC50
= 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50
= 18 μ
M). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50
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Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis.
Hershberger et al.
Probe Reports from the NIH Molecular Libraries Program, 2012;