ML 347

Key Product Details

Product Description

ML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC₅₀ values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC₅₀ = 152 nM).

Product Specifications for ML 347

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for ML 347

The following data is based on the product molecular weight 352.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.19 mL	70.94 mL	141.89 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
2 mM	1.42 mL	7.09 mL	14.19 mL
10 mM	0.28 mL	1.42 mL	2.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Engers Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN Bioorg Med Chem Lett. 2013 PMID: 23639540

Product Documents for ML 347