Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Biological ActivityML 347 is a potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN
Engers et al.
Bioorg Med Chem Lett., 2013;23:3248
Citation for ML 347
The citations listed below are publications that use Tocris products. Selected citations for ML 347 include:
1 Citation: Showing 1 - 1
Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.
Authors: Varadaraj Et al.
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