Catalog Number: 4945
Alternate Names: LDN 193719, 1lWY, VU0469381
Chemical Name: 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Biological Activity
Potent and selective ALK2 and ALK1 inhibitor (IC50 values are 32 and 46 nM, respectively); displays >200 fold selectivity over ALK3 and ALK6 and >400 fold selectivity over VEGF2. Exhibits no activity at ALK4, ALK5 or in a panel of related kinases. Inhibits BMP4 signaling in a functional assay (IC50 = 152 nM).
Technical Data
  • M.Wt:
    352.39
  • Formula:
    C22H16N4O
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1062368-49-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN
    Engers et al.
    Bioorg Med Chem Lett., 2013;23:3248
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ML 347 include:

1 Citations: Showing 1 - 1

  1. Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.
    Authors: Varadaraj Et al.
    Neoplasia 2015;17:826

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