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ML 348

Catalog #: 5345
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5345/10
5345/50
ML 348 | CAS No. 899713-86-1 | Hydrolase Inhibitors
1 Image
Description: Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor

Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

ML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.

Technical Data

M.Wt:
415.79
Formula:
C18H17ClF3N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
899713-86-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Complete Your Experiment

ML 349
Cat # 5344

Background References

  1. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2).
    Adibekian et al.
    Probe Reports from the NIH Molecular Libraries Program, 2013;
  2. APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells.
    Hernandez et al.
    Cell Chem.Bio., 2017;24:87

Product Datasheets

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Citations for ML 348

The citations listed below are publications that use Tocris products. Selected citations for ML 348 include:

2 Citations: Showing 1 - 2

  1. Palmitoylation is required for TNF-R1 signaling.
    Authors: Zingler Et al.
    Cell Commun Signal  2019;17:90
  2. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells.
    Authors: Vujic Et al.
    Oncotarget  2016;7:7297

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