Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Biological ActivityML 348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2).
Adibekian et al.
Probe Reports from the NIH Molecular Libraries Program, 2013;
APT2 inhibition restores Scribble localization and S-palmitoylation in Snail-transformed cells.
Hernandez et al.
Cell Chem.Bio., 2017;24:87
Citations for ML 348
The citations listed below are publications that use Tocris products. Selected citations for ML 348 include:
2 Citations: Showing 1 - 2
Palmitoylation is required for TNF-R1 signaling.
Authors: Zingler Et al.
Cell Commun Signal 2019;17:90
Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells.
Authors: Vujic Et al.
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