MLi-2
Chemical Name: rel-3-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-pyrimidyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole
Purity: ≥98%
Biological Activity
MLi-2 is a potent and selective LRRK2 inhibitor (IC50 = 0.76-3.4 nM depending on assay), which exhibits >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. MLi-2 is centrally bioavailable and active in vivo.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of MLi-2 is reviewed on chemicalprobes.org and the SGC website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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MLi-2, a potent, selective, and centrally active compound for exploring the therapeutic potential and safety of LRRK2 kinase inhibition.
Fell et al.
J.Pharmacol.Exp.Ther., 2015;355:397
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Citation for MLi-2
The citations listed below are publications that use Tocris products. Selected citations for MLi-2 include:
1 Citation: Showing 1 - 1
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LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
Authors: Henderson Et al.
Acta Neuropathol Commun 2018;6:45
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