MLi-2

Catalog # Availability Size / Price Qty
5756/10
5756/50
MLi-2 | CAS No. 1627091-47-7 | LRRK2 Inhibitors
1 Image
Description: Potent and selective LRRK2 inhibitor

Chemical Name: rel-3-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-pyrimidyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

MLi-2 is a potent and selective LRRK2 inhibitor (IC50 = 0.76-3.4 nM depending on assay), which exhibits >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. MLi-2 is centrally bioavailable and active in vivo.

External Portal Information

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of MLi-2 is reviewed on chemicalprobes.org and the SGC website.

Technical Data

M.Wt:
379.46
Formula:
C21H25N5O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1627091-47-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for MLi-2

The citations listed below are publications that use Tocris products. Selected citations for MLi-2 include:

1 Citation: Showing 1 - 1

  1. LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons.
    Authors: Henderson Et al.
    Acta Neuropathol Commun  2018;6:45

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