MM 102

Key Product Details

Product Description

MM 102 is a potent WDR5/MLL interaction inhibitor (IC₅₀ = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.

Product Specifications for MM 102

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for MM 102

The following data is based on the product molecular weight 783.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.28 mL	6.38 mL	12.76 mL
5 mM	0.26 mL	1.28 mL	2.55 mL
10 mM	0.13 mL	0.64 mL	1.28 mL
50 mM	0.03 mL	0.13 mL	0.26 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Karatas High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc. 2013 PMID: 23210835

Product Documents for MM 102