Potent WDR5/MLL interaction inhibitor (IC50
= 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9
gene expression in leukemia cells expressing the MLL1-AF9
fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction.
Karatas et al.