MMP-2 Antibody (MMP2/1501)

Novus Biologicals | Catalog # NBP2-53404

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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Protein Array

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # MMP2/1501
View all MMP-2 Primary Antibodies »

Product Specifications

Immunogen

Recombinant human MMP-2 protein fragment (aa 444-575) (exact sequence is proprietary) (Uniprot: P08253)

Localization

Cytoplasmic and Cell Surface

Marker

Tumor Metastasis Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-54364)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Scientific Data Images for MMP-2 Antibody (MMP2/1501)

Western Blot: MMP-2 Antibody (MMP2/1501) [NBP2-53404]

Western Blot: MMP-2 Antibody (MMP2/1501) [NBP2-53404]

Western Blot: MMP-2 Antibody (MMP2/1501) [NBP2-53404] - (1) Recombinant MMP2 protein and (2) U87 Cell Lysate using MMP2 Monoclonal Antibody (MMP2/1501).
Protein Array: MMP-2 Antibody (MMP2/1501) [NBP2-53404]

Protein Array: MMP-2 Antibody (MMP2/1501) [NBP2-53404]

Protein Array: MMP-2 Antibody (MMP2/1501) [NBP2-53404] - Analysis of Protein Array containing more than 19,000 full-length human proteins using MMP-2 Antibody (MMP2/1501) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5.

Applications for MMP-2 Antibody (MMP2/1501)

Application
Recommended Usage

Western Blot

1-2 ug/ml
Application Notes
Optimal dilution for a specific application should be determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: MMP-2

MMP2 is a member of the Matrix Metalloproteinase (MMP) family, which are involved in extracellular matrix degradation under both normal physiological and disease processes. Specifically, MMP-2 is responsible for degrading collagens type IV, V, VII, and X and gelatin type I. Other reported functions of MMP 2 include angiogenesis, tumor invasion, tissue repair, remodeling of the vasculature, inflammation, and atherosclerotic plaque rupture. MMP-2 secretion is activated by the Ras signaling pathway. MMP2 triggers cells to begin migration by cleaving laminin-5 and exposing an integrin-binding site on the epithelial basement membrane. The cleaved of laminin has been detected in tumors and in tissues being altered, howver the activated form of MMP2 is not found in benign tumors. Thus, detection of MMP2 is a possible early indicator of tumor activity. MMP2 is most strongly expressed in normal skin fibroblasts, but may also be found in gliomas, breast and prostate tumors. Mutations in the MMP-2 gene have been linked to Torg-Winchester syndrome, Nodulosis-Arthropathy-Osteolysis (NAO) syndrome, and arthritis. Additionally, abnormal expression of matrix matalloproteinases have been associated with neoplastic traits such as loss of negative growth regulation and high invasive potential.

Long Name

Matrix Metalloproteinase 2

Alternate Names

Gelatinase A, MMP2

Gene Symbol

MMP2

UniProt

P08253

Additional MMP-2 Products

Product Documents for MMP-2 Antibody (MMP2/1501)

Certificate of Analysis

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Product Specific Notices for MMP-2 Antibody (MMP2/1501)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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