MMP26 Antibody (24GB13675)

Novus Biologicals | Catalog # NBP3-50918

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB13675
View all MMP-26 Primary Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human MMP26 (Uniprot: Q9NRE1)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for MMP26 Antibody (24GB13675)

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: MMP-26

Matrix metalloproteinase 26 (MMP-26) is specifically expressed in cancer cells of epithelial origin, including carcinomas of lung, prostate and breast. Several unique structural and regulatory features, including an unusual 'cysteine-switch' motif, discriminate broad-spectrum MMP-26 from most other MMPs. MMP-26 efficiently cleaves fibrinogen and extracellular matrix proteins, including fibronectin, vitronectin and denatured collagen (1). Expression analysis revealed that matrilysin-2 is detected not only in placenta and uterus but is widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines. These data together with its broad spectrum of proteolytic activity, suggest that MMP-26 may play a role in some of the tissue-remodeling events associated with tumor progression (2). A study of MMP-26 mRNA steady states levels reveals, among the tissue examined, a specific expression in placenta. MMP-26 mRNA could also be detected in several human cell lines such as HEK 293 kidney cells and HFB1 lymphoma cells (3)

Long Name

Matrix Metalloproteinase 26

Alternate Names

Endometase, Matrilysin 2, MMP26

Gene Symbol

MMP26

Additional MMP-26 Products

Product Documents for MMP26 Antibody (24GB13675)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for MMP26 Antibody (24GB13675)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Metalloproteases and Regulators

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