Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

Novus Biologicals | Catalog # NBP3-08151

Novus Biologicals
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Key Product Details

Sample Type & Volume Required Per Well

Serum, Plasma, Cell supernatant

Sensitivity

0.19 ng/mL

Assay Range

0.31 - 20 ng/mL
View all MMR/CD206 ELISA Kits »

Product Specifications

Assay Type

Sandwich-ELISA

Kit Type

ELISA Kit (Colorimetric)

Species

Human

Precision

Intra-Assay Precision (Precision within an assay) %CV 6.19

Inter-Assay Precision (Precision between assays) %CV 6.93

Recovery for Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

Recovery

93 - 109%

Linearity

Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

Scientific Data Images for Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

ELISA: Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric) [NBP3-08151] -

ELISA: Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric) [NBP3-08151] - Standard Curve Reference

Kit Contents for Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

  • Micro ELISA Plate (Dismountable) - 1 EA, Reference Standard - 2 vials, Concentrated Biotinylated Detection Ab (100X) - 120 uL, Concentrated HRP Conjugate (100X) - 120 uL, Reference Standard & Sample Diluent - 20 mL, Biotinylated Detection Ab Diluent - 14

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: MMR/CD206

The Mannose Receptor (MR), a member of the vertebrate C-type lectin family, is a pattern recognition receptor that is involved in both innate and adaptive immunity. The 180 kDa transmembrane protein consists of 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail.The structure is shared by the family of multi lectin mannose receptors: the phospholipase A2-receptor, DEC 205 and the novel C-type lectin receptor (mannose receptor X). The MR recognises a wide range of gram positive and gram negative bacteria, yeasts, parasites and mycobacteria. The MR has also been shown to bind and internalize tissue-type plasminogen activator. MR's are present on monocytes and dendritic cells (DC) and are presumed to play a role in innate and adaptive immunity, the latter via processing by DC. The expression of MR as observed in immunohistology is present on tissue macrophages, dendritic cells, a subpopulation of endothelial cells, Kupffer cells and sperm cells. The expression of MR on monocytes increases during culture and can be enhanced by cytokines such as IFN-gamma. Labeling of MR expressing monocytes/macrophages increases with prolonged incubation time probably due to internalization of the MR-antibody-complex. The antibody 15-2 prevents binding of glycoproteins including t-PA to MR. Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific.

Long Name

Macrophage Mannose Receptor

Alternate Names

CD206, CLEC13D, MRC1

Gene Symbol

MRC1

Additional MMR/CD206 Products

Product Documents for Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

Certificate of Analysis

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Product Specific Notices for Human MMR/CD206/Mannose Receptor ELISA Kit (Colorimetric)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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